Injury Expert Predicts Joe Mixon’s Worst Nightmare as the RB’s Season in Jeopardy

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That agonizing limbo between maybe and never, For Joe Mixon the nightmare isnt just the gnawing ache in his ankle, its something much dire, as his season seems to be in a pretty precarious situation; some might just call it a jeopardy with a lingering injury threatening his 2025 campaign and week 1 availability, as the cautions approach “The Texans will take their time…will not rush him back” now this? It’s prudent, but it masks a chilling possibility: the surgical suite.

Rewind to 2024: Mixon slicing through the defenses for 1,016 yards (245 carries), snagging 36 catches and punching in TDs, he wasn’t just productive; he was Houston’s soul. Fast forward to today? That ankle has become the nesting doll of misery. One expert predicts, “The Texans will take their time with managing his recovery and will not rush him back onto the field after missing the entire offseason and the majority of training camp so far. I expect Mixon to start on the PUP, and miss at least the first 4 games of the season.” Worse still? “I believe there is a scenario where he undergoes a season-ending surgery after struggling with non-surgical options.”

Joe Mixon update

– a lingering foot-ankle injury
– he suffered away from the Texans
– progressed from a walking boot to wearing a brace to having increased mobility over the summer
– now he’s out indefinitely while rehabbing – – he’s navigating a somewhat complicated…

— Jesse Morse, M.D. (@DrJesseMorse) August 16, 2025

His offseason journey reads like a medical chart: walking boot to brace to fleeting mobility… and now, silence. He’s out indefinitely, firmly planted on the non-football injury list, navigating what’s described as “a somewhat complicated medical issue”. Could he truly be inching towards living his worst nightmare, missing out on the whole season?

Mixon has often highlighted the importance of giving his all on every play: “Every play, every second, give it everything.” Career-wise, he’s played 111 games, racking 7,428 rushing yds on 1,816 carries, a 4.1 avg, and 60 rushing TDs. Add 319 receptions for 2,448 yds and 14 receiving TDs, and you start to understand why this injury is seismic. Two Pro Bowl nods (2021, 2024) and a playoff performance that included 194 yards and 2 TDs over 2 games? That’s Mixon being Mixon—dynamic, reliable, and right now, frustratingly absent.

Rob Connello, part of Mixon’s care team, recently posted a glimpse into the fight as well. “Grateful for the opportunity to work with Houston Texans RB Joe Mixon, being part of your care team and helping you reach your goals was truly an honor. Even better – learning from fellow clinicians and gaining insight from an elite athlete’s perspective. Appreciate the experience.” The respect is palpable, the struggle? Implied.

Yet Texans fans clutch their jerseys tighter. They’ve seen this film before—the star felled, the dream deferred. But Mixon’s nightmare cuts deeper. It’s not just bone and ligament betraying him. It’s the creeping dread that after the boot, the brace, and the shockwaves… the only card left to play is the one that ends the game. So, where does that leave the Texans’ squad staring down a SB window?

Suddenly, Texans RB Mixon’s week one status is in doubt; it’s not just a headline, it’s the defining subplot of their preseason.

Backfield in flux: SB aspirations hinge on Mixon

The ripple effect is immediate; the backfield, envisioned with Mixon as the undisputed RB1, now scrambles for identity. Dameon Pierce, himself on the PUP list, adds another layer of uncertainty. The burden shifts, for now, to a committee whispering of grit over glamour.

The medical expert added his opinion on the Texans’ RB room, “The backfield will likely be led by Dameon Pierce and there will be sprinkle of Nick Chubb, Dare Ogunbowale and Woody Marks.” Chubb, the veteran addition recovering from his own brutal knee injury, represents a fascinating ‘what if’. Can he recapture even a fraction of his Cleveland dominance?

Ogunbowale brings special team value and steady hands with stats of 166-569. Rookie Woody Marks, on the other hand, carries the unknown promise of youth and 3,016 yards on 608 carries, with an astounding 31 touchdowns; it’s a patchwork quilt sewn with necessity, a stark contrast to the explosive certainty Mixon offered just months ago.

While CJ Stroud loses a trusted safety valve, the play-action game loses its teeth, and the dream of a balanced, relentless attack feels suddenly fragile. Why?

· Stroud’s Safety Net Gone: 3rd-and-4? Mixon was the bailout (36 rec, 309 yds in ‘24).
· Play-Action Magic Fizzling: No threat of Mixon’s fury? Safeties squat on Collins/Kirk/Higgins.
· The PUP Dominoes: Miss 4 games? The AFC South won’t wait.

The Hope is for a triumphant return, but the shadow of the worst-case scenario, the surgeon’s light, and the lost season? It lingers, a stark reminder of how quickly an NFL dream can pivot, as the Texans‘ season, brimming with promise, now holds its breath waiting on one man’s healing foot.

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